| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 26-4-25 20:30 | Toronto FC | New York City FC | 0:1 |
| 26-4-25 20:30 | FC Cincinnati | Sporting Kansas City | 2:1 |
| 26-4-25 22:30 | Philadelphia Union | D.C. United | 3:0 |
| 26-4-25 22:30 | New York Red Bulls | CF Montreal | 1:0 |
| 27-4-25 1:15 | Orlando City | Atlanta United FC | 3:0 |
| 27-4-25 1:30 | San Diego FC | Real Salt Lake | 1:3 |
| 27-4-25 1:30 | Columbus Crew | San Jose Earthquakes | 2:1 |
| 27-4-25 1:30 | Charlotte FC | New England Revolution | 0:1 |
| 27-4-25 2:30 | Houston Dynamo | Austin FC | 2:0 |
| 27-4-25 2:30 | Nashville SC | Chicago Fire | 7:2 |
| 27-4-25 3:30 | Colorado Rapids | Seattle Sounders | 1:1 |
| 27-4-25 21:00 | Minnesota United FC | Vancouver Whitecaps | 1:3 |
| 27-4-25 23:00 | Inter Miami CF | FC Dallas | 3:4 |
| 28-4-25 1:00 | Los Angeles FC | St. Louis City SC | 2:2 |
| 28-4-25 3:00 | Los Angeles Galaxy | Portland Timbers | 2:4 |